Gene Delivery with Dual pH- and GSH-Responsive Lipoamide Polymers from Controlled Polymerization of Protected Lipoic Acid

Abstract

Gene delivery has great therapeutic potential, but there remain significant barriers for the effective use of this technology, including efficient transportation of the genetic payloads to the region of the cell where they are therapeutically active. Nanoparticle delivery systems have emerged as an important tool to improve the targeted delivery of nucleic acid cargo inside cells. Stimuli-responsive systems have generated particular interest for this application due to their capability to tailor the packing and effective release of nucleic acid cargo. Herein, we report dual pH- and glutathione (GSH)-responsive poly(lipoamide) (PLpAm) nanoparticles for the delivery of plasmid DNA (pDNA). PLpA..